Facebook stock has highest close since May 21

NEW YORK (AP) -- Facebook closes at one of its highest prices since its initial public offering.

The stock rose $1.21, or 3.8 percent, to finish Friday at $33.05. It hasn't closed above that price since May 21, the second day of trading.

The stock finished the week up 10 percent, the second straight week of increase.

Facebook is still 14 percent below its IPO price of $38 a share.

Facebook's IPO has had a rocky ride. Its debut was delayed by trading glitches on the Nasdaq.

Investors have been concerned about its ability to increase revenue and make money from its growing mobile audience, though many analysts hold positive long-term opinions.

Facebook, along with investment banks that led the IPO, is the subject of dozens of shareholder lawsuits.

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Space Plane: X-37B Video Shows Air Force Craft's Robotic Landing

By: Mike Wall
Published: 06/17/2012 12:10 AM EDT on SPACE.com

The U.S. Air Force's robotic X-37B space plane came back to Earth today (June 16) after 15 months in orbit on a mystery mission, and its much-anticipated landing was caught on video.

The X-37B spacecraft touched down at California's Vandenberg Air Force Base at 5:48 a.m. local time Saturday (8:48 a.m. EDT; 1248 GMT). Several hours later, Vandenberg officials released a short video of the event.

The first part of the 80-second video was apparently shot in infrared light. It shows the X-37B space plane cruising in for an automated landing, its belly and nose glowing a bright orange-yellow, presumably from the heat generated during re-entry to Earth's atmosphere.

The video switches over to visible wavelengths about 35 seconds in, after the space plane has touched down, and shuts off shortly after the X-37B rolls to a stop on the runway. [Photos: Air Force's 2nd Secret X-37B Mission]

The X-37B, also known as Orbital Test Vehicle-2 (OTV-2), launched on March 5, 2011, from Florida's Cape Canaveral Air Force Station. Its flight was the second-ever mission for the X-37B program; the first was flown by OTV-2's sister ship, OTV-1.

OTV-1 blasted off in April 2010 and stayed aloft for 225 days, well below the supposed 270-day orbital limit for the space plane. But OTV-2 smashed that limit, zipping around our planet for 469 days before finally coming down today.

Just what OTV-2 was doing up there for so long remains a mystery. Details of the vehicle's mission are classified, as are its payloads. The secrecy has spurred speculation ? notably from China ? that the X-37B may be a space weapon of some sort, but Air Force officials have long insisted that the spacecraft is simply testing out technologies for future satellites.

The X-37B looks like NASA's recently retired space shuttle, but it's far smaller. The X-37B is 29 feet (8.8 meters) long and 15 feet (4.5 m) wide, with a payload bay about the size of a pickup truck bed. For comparison, two X-37B vehicles could fit inside the payload bay of a space shuttle.?

The 11,000-pound (5,000-kilogram) space plane's orbital longevity is enabled by its solar array, which generates power after deploying from the payload bay.

The X-37B is built by Boeing, though NASA originally used the vehicle as an experimental test bed until funding for the project ran out in 2004. The space plane then passed to the Defense Advanced Research Projects Agency, and it was ultimately turned over to the Air Force in 2006.

Follow SPACE.com senior writer Mike Wall on Twitter @michaeldwall or SPACE.com @Spacedotcom. We're also on Facebook and Google+.

Copyright 2012 SPACE.com, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

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PURITY Correctional Camp

PURITY is a facility that prides itself on relieving teens of their homosexual urges, and like it or not, you're now a part of this program. Will you resist, or try to change yourself? Either way, it's certainly not going to be a typical camp experience.

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This topic is an Out Of Character part of the roleplay, ?PURITY Correctional Camp?. Anything posted here will also show up there.

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Forum for completely Out of Character (OOC) discussion, based around whatever is happening In Character (IC). Discuss plans, storylines, and events; Recruit for your roleplaying game, or find a GM for your playergroup.

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France seeks 120 bln EU package, euro bonds later

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McCain: Romney receiving foreign money for campaign (Americablog)

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Hidden vitamin in milk yields remarkable health benefits

ScienceDaily (June 14, 2012) ? A novel form of vitamin B3 found in milk in small quantities produces remarkable health benefits in mice when high doses are administered, according to a new study conducted by researchers at Weill Cornell Medical College and the Polytechnic School in Lausanne, Switzerland.

The findings, recently reported in the June 2012 issue of the journal, Cell Metabolism, reveal that high doses of the vitamin precursor, nicotinamide riboside (NR) -- a cousin of niacin -- prevent obesity in mice that are fed a fatty diet, and also increase muscle performance, improve energy expenditure and prevent diabetes development, all without side effects.

The Swiss researchers, led by Dr. Johan Auwerx, performed the mouse experiments, while the ability to give the animals sufficient doses of NR was made possible by Weill Cornell Medical College researchers, who played key roles in uncovering the biological story of NR.

"This study is very important. It shows that in animals, the use of NR offers the health benefits of a low-calorie diet and exercise -- without doing either one," says Dr. Anthony Sauve, associate professor of Pharmacology at Weill Cornell Medical College.

Dr. Sauve is the pharmacologist and organic chemist who has invented a simple method for efficiently synthesizing NR in large scale. He was first to show that NR increases nicotinamide adenine dinucleotide (NAD) levels in mammalian cells. NAD is a central player in energy metabolism. He has pioneered research into the compound, and he is a leader in investigating how NAD can signal adaptation in cells and in physiology.

"The research also suggests that the effects of NR could be even broader," Dr. Sauve says. "The bottom line is that NR improves the function of mitochondria, the cell's energy factories. Mitochondrial decline is the hallmark of many diseases associated with aging, such as cancer and neurodegeneration, and NR supplementation boosts mitochondrial functioning."

The Swiss researchers call NR a "hidden vitamin" that is believed to also be present in many other foods, although levels are low and difficult to measure. Nevertheless, the effects of NR on metabolism "are nothing short of astonishing."

Got nicotinamide riboside?

The study depended on a series of crucial discoveries by Dr. Sauve and his laboratory colleagues.

NR, related to niacin and other common forms of vitamin B3, was first investigated more than 60 years ago by a Stanford researcher and 1959 Nobel Laureate, Arthur Kornberg. But little more was known about its effects in mammals until Dr. Sauve discovered the effect NR had in stimulating levels of NAD in mammalian cells -- work he published in 2007.

NAD allows sugars, fats, and proteins to be converted into energy. Dr. Sauve's research provided the first evidence that NR enhances NAD levels in the mitochondria in mammalian cells in culture. These findings are published in the current study. These cell-based observations were key to the demonstration that NR could stimulate tissue NAD levels in animals, and that it could stimulate NAD-dependent sirtuins, which adapt physiology to the low calorie diets that are known to extend the lifespan of many organisms.

Dr. Sauve invented a relatively simple method for efficiently synthesizing NR in large scale so that its health benefits can be studied. This methodology, which makes it possible to make NR commercially available, was patented by Cornell's Center for Technology Enterprise and Commercialization and subsequently licensed to ChromaDex Corporation.

The development of a means to synthesize NR in adequate quantities was crucial to the current research, and the Sauve lab provided methods and NR to make the study possible. In addition, the biological observations on the effects of NR on NAD levels in cells and on mitochondria were key to the study. Finally, the Sauve laboratory has developed state of the art analytical methods to determine NAD levels in cells, tissues and organelles, and the laboratory provided several key metabolic measurements highlighted in the study.

"Our published scientific work has verified that NR is perhaps the most potent NAD enhancing agent ever identified," he says. His laboratory is also widely recognized for developing an expertise in the measurement of NAD metabolism in cell tissues.

With this compound, the Swiss researchers found that mice on a high-fat diet supplemented with NR gained significantly less weight (60 percent) than mice fed the same diet without NR, even though the mice supplemented with NR ate the same amount of food as mice on the high fat diet not treated with NR. They had improved energy. They were in better shape than the untreated mice, with significantly better endurance and stronger muscles. Additionally, none of the treated mice developed diabetes, as seen in the untreated mice on the high fat diet. And when fed a normal diet, NR treated mice had improved sensitivity to insulin. The NR treated mice also showed lower cholesterol levels. All of these benefits came without toxicity.

While the new study demonstrates that high doses of NR can largely prevent the negative health consequences of a poor diet in mice, Dr. Sauve stresses that the effects of high doses of the vitamin in humans have not been evaluated. "It is important to keep in mind that the amount of NR in milk and other foods appears to be small. We don't know what effects NR would have in humans at relatively high doses," he says.

"Still, we have very encouraging evidence of benefits of NR and NAD augmentation in general from this animal study -- and much more work to do," he says.

The study's senior investigator Dr. Auwerx is head of Laboratory of Integrative Systems Physiology at the Polytechnic School in Lausanne (?cole Polytechnique F?d?rale de Lausanne or EPFL) and the first author is Dr. Carles Cant?, also of EPFL.

Other co-authors include Dou Y. Youn and Dr. Yana Cen from Weill Cornell Medical College; Dr. Riekelt H. Houtkooper, Dr. Eija Pirinen, Dr. Maaike H. Oosterveer, Dr. Pablo J. Fernandez-Marcos, Dr. Hiroyasu Yamamoto, Dr. P?n?lope A. Andreux, Dr. Philippe Cettour-Rose, Dr. Kristina Schoonjans and Dr. Chris Rinsch from EPFL; Dr. Karl Gademann from the University of Basel in Switzerland.

The Ellison Medical Foundation New Scholar Award and the New York State Spinal Cord Injury Board funded study contributions by the Weill Cornell Medical College researchers.

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Story Source:

The above story is reprinted from materials provided by NewYork-Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

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Journal Reference:

1. Carles Cant?, Riekelt?H. Houtkooper, Eija Pirinen, Dou?Y. Youn, Maaike?H. Oosterveer, Yana Cen, Pablo?J. Fernandez-Marcos, Hiroyasu Yamamoto, P?n?lope?A. Andreux, Philippe Cettour-Rose, Karl Gademann, Chris Rinsch, Kristina Schoonjans, Anthony?A. Sauve, Johan Auwerx. The NAD Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity. Cell Metabolism, 2012; 15 (6): 838 DOI: 10.1016/j.cmet.2012.04.022

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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